What's New

scheme2_v3

August 22, 2014: Our new research article has been published in JBC

We are co-authors of the paper entitled ‘Magnesium modulates actin binding and ADP release in myosin motors.’, which has been published in The Journal of Biological Chemistry. Our data on transient Mg binding kinetics with single tryptophan probes in the switch I (Trp-239) and switch II (Trp-501) region of  Dictyostelium myosin II demonstrate these conserved regions of the active site are sensitive to Mg(2+) coordination. Overall, our results suggest that Mg(2+) reduces the ADP release rate constant and rate of attachment to actin. Swenson AM et al. J Biol Chem. 2014 Aug 22;289(34):23977-91.

  • Contact

  • Archives

  • Funding